Key Benefits:
On 12 April 2010 (State 1 Er May 2010)
This Order governs:
(art. 121 OPAn)
1 Technical installations, such as ventilation and automatic watering systems, are to be secured by means of an alarm if their failure, due to a breakdown or malfunction, would result in damage to the animals.
2 The state of the environment in which animals are held, including litter, food and water, as well as animal welfare, will be monitored daily.
3 The well-being of small rodents is controlled when they are transferred to clean cages. These animals will also be subject to visual examination three times a week at least. It is not necessary to monitor the state of the environment and the well-being of small rodents on weekends if concrete data on past surveillance attest to the fact that animals do not suffer from the lack of control.
4 Small rodents refer to the animals listed in Appendix 3, Table 1, OPAn.
5 In the case of a finding of a constraint in an animal, it will be reported on the cage or enclosure by the affixing of distinctive marks.
6 The frequency of controls referred to in paras. 2 and 3 will be increased depending on the strain on the animals.
7 The results of the checks carried out are to be recorded in minutes.
(art. 119, para. 2, OPAn)
The dates of the start and end of the individual detention of socially incompatible animals, as well as the particular facts observed during that detention, are to be recorded in minutes.
(art. 71, para. 2, OPAn)
The exit of the dogs can take place in an open-air enclosure.
(art. 120 OPAn)
1 Marking of small rodents for breeding can be done using invasive methods such as tattooing, electronic chip placement, ear piercing or the amputation of the distal phalanx of a finger.
2 The marking of small non-breeding rodents using invasive methods is only possible if justified by the relevant experience and will always have to be motivated.
3 Marking by means of ear tags is prohibited.
4 The necessary labelling for genotyping is to be combined with the biopsy.
(art. 135, para. 9, OPAn)
The following actions and measures may be taken at the premises where the animals are held:
(art. 114 OPAn)
1 The assignment of persons to the care of experienced animals and their working instructions will be listed in an understandable manner.
2 In the pet store, it will be clearly stated for each animal that is responsible for compliance with the animal protection provisions.
3 Documentation of the stress characterization and the criteria for stopping the experiment should be available to staff at any time.
(art. 116 OPAn)
At least one-third of equivalent full-time equivalent jobs in animal care must be filled by persons who have been trained as an art keeper. 195 OPAn.
(art. 142, para. 4, OPAn)
1 Recognized methods of producing genetically modified animals are listed in Appendix 1.
2 A method can be recognized if it is widely used and if, in comparison to other processes, it is respectful of animals. The criteria to be taken into account are both the implementation of the interventions and the measures that the success rate and the number of animals supernumerary.
3 Recognized methods will be applied in an animal-friendly manner and in accordance with a standard protocol.
4 The animalies shall make available to the Cantonal Authority a record of the success rate in the application of the accepted methods. If this rate is insufficient, the pet shop will take appropriate corrective action.
(art. 120, para. 1 and 123, OPAn)
1 The following methods or combination of methods are allowed for genotyping in the production and rearing of genetically modified animals:
2 Tail biopsies are allowed only if they are justified by the relevant and motivated experience. It is forbidden to take more than 5 mm from the tail.
3 The following methods combining tagging and genotyping are allowed in small rodents:
(art. 124 OPAn)
The sacrifice of animals for anatomical or pathological purposes and examinations such as light stress tests and blood samples are permitted in the production and breeding of lines or strains Animals if they are performed to describe the characteristics of the lines and strains. These examinations will be carried out in an animal-friendly manner.
(art. 124 OPAn)
1 Characterization of stress in small rodents will be documented. This will include:
2 The frequency of the controls and the specific signs to be searched will be re-examined on the basis of the results of the monitoring or experience.
3 The measures reducing the constraint and the criteria for stopping the experiment will be applied without delay. This application will be documented.
(art. 124 OPAn)
1 The leader of the animalerie is responsible for the strain characterization in small rodents. In particular, it ensures that:
2 The list of specific signs to be controlled within the meaning of Annex 4 must be completed for each line by the specific signs which, because of the genetic modification concerned, are likely or at least possible.
3 Information from the stress characterization, as well as data on reproduction and mortality, will be evaluated as they are acquired and compared with available information and data on Animals with the same genetic background.
(art. 124 OPAn)
1 New or insufficiently characterized lines of small, genetically modified rodents will be controlled during the change of cage to detect any specific signs within the meaning of Annex 4, and will be the subject of a simple Visual inspection at least once between each change of cage.
2 Newborns will be screened within five days of birth to identify any specific signs within the meaning of Schedule 4. They will then be controlled at the rate set out in para. 1 to weaning.
3 All animals referred to in paras. 1 and 2 will be monitored for the first three generations.
4 A line is deemed not to have a debilitating phenotype if a total of 100 animals obtained in at least three generations have been controlled and no constraints have been detected in these controls.
(art. 124 OPAn)
1 A line of small rodents is considered likely to present a constraint:
2 In the case of strains capable of presenting a stress, the characterization of the constraint is carried out in accordance with art. 14.
(art. 124 OPAn)
In the incapacitating phenotype, the extent of the controls and the list of specific signs to be examined and documented will be specified in the decision under s. 127 OPAn.
(art. 126 and 145, para. 1, let. A, OPAn)
1 If several small rodents from new or insufficiently characterized lines or genetically modified lines likely to have a debilitating phenotype have similar constraints, the leader of the animalerie shall notify the Constraints observed in the Cantonal Authorization Authority (interim notification).
2 The provisional notification must contain the following information:
3 The provisional notification shall be transmitted within two weeks of the finding of the constraints.
4 If the constraints identified in the stress characterization are confirmed, the leader of the animal will make a definitive notification within the meaning of s. 18. If the constraints initially identified are not confirmed, it will also notify the cantonal authority.
(art. 126 and 145, para. 1, let. A, OPAn)
1 The definitive notification of stresses in small rodent lines is to be carried out at the latest after 100 animals have been checked in accordance with art. 14.
2 The final notification shall contain the following data:
(art. 124 OPAn)
1 Characterization of stress in novel or uncharacterized inbred lines of genetically modified fish includes:
2 Breeding data will be analyzed as they are acquired and compared with available data for animals with the same genetic background.
(art. 124 OPAn)
1 A fish line is likely to have a disabling phenotype:
2 The stress characterization in fish lines that are capable of presenting a debilitating phenotype is carried out in accordance with art. 19.
(art. 124 OPAn)
In fish lines with a debilitating phenotype, the scope of controls and the list of specific signs to be monitored and documented will be specified in the decision under s. 127, OPAn.
(art. 126 and 145, para. 1, let. A, OPAn)
The notification of a line of genetically modified fish with a disabling phenotype shall contain the information referred to in Art. 126, para. 2, OPAn, including the weighing of interest referred to in s. 18, para. 2, let. D of this order.
(art. 124 OPAn)
1 The main information on the genetically modified lines and the mutants with a disabling phenotype are to be entered on a summary document (data sheet). This data sheet should contain the following information:
2 The data sheet shall be given to the cantonal authority at the latest at the time of the application for authorisation to practice animal experiments with the line or mutants in question, or when notification of the line or mutants to the The cantonal authority.
3 The data sheet is a communication within the meaning of s. 13 of the Order of August 25, 1999, on the use of confined organisms 1 In the case of the transfer of genetically modified animals from one enclosed environment into another. At the time of the transfer of a new lineage that has not yet been sufficiently characterized or of a lineage capable of presenting a disabling phenotype, it will also be given to the recipient all the data collected on that date.
1 [ RO 1999 2783 , 2003 4793 Ch. I 3, 2006 4705 ch. II 82, 2007 4477 ch. IV 35, 2008 4377 Annex 5, c. 6. AS 2012 2777 art. 33 hp. 1]. See currently O of 9 May 2012 (RS 814.912 ).
(art. 136, para. 2, OPAn)
Constraints caused by interventions or measures taken in the context of an animal experiment are classified in one of the following four categories:
(art. 136, para. 2, OPAn)
The constraints caused by genetic modification are classified into four categories:
(art. 136, para. 2, OPAn)
In assessing the proportionality of an experiment, account shall be taken of the constraints referred to in Art. 24 and 25 and other stresses suffered by animals due to their oiling, profound interventions in their phenotype or in their abilities, or excessive instrumentalization.
(art. 139, para. 2, OPAn)
1 Notifications concerning experiments carried out in several cantons must mention the number of animals used in each of the cantons.
2 If the animals are moved from one canton to another in the course of experience, their number will be entered only in the canton where the experience has taken place mainly.
(art. 122 OPAn)
The application for authorization to operate a pet store must contain the following information:
(art. 145, para. 1, let. B, OPAn)
1 The statements to be made by the animals must contain the following information:
2 The number of animals must be mentioned by animal species.
3 Lines with a disabling phenotype must be reported individually. Their names and the names on their respective data sheets must correspond.
4 If the lines do not have a debilitating phenotype, they must be reported for each animal species by grouping:
(art. 139, para. 1, OPAn)
The application for authorisation to conduct animal experiments shall contain the following information:
(art. 145, para. 2, OPAn)
1 The declarations on animal experiments should contain the following information:
2 Statements must be made in all cases, whether or not the experience occurred.
(art. 9, para. 1)
(art. 17, para. 2, let. B, 18, para. 2, let. A and 23, para. 1, let. (a)
The following information on breeding lines should be provided:
(art. 23, para. 1, let. (b)
The following information regarding the execution of the stress characterization and its result should be provided:
(art. 12, para. 1, let. A, 13, para. 2 and 14, para. 1 and 2)
Table 1: Characterization of stress in genetically modified small rodent lines and in mutants with a debilitating phenotype
Nest Controls (art. 14, para. 2 and 15, para. 2) |
Controls when changing the cage (art. 14, para. 1 and 15, para. 2) |
|
Number of youth, colour, size differences |
X |
X |
Food (milk spot) |
X |
|
General health status (size, tone, nutritional status, etc.) |
X |
X |
Malformations visible to the naked eye |
X |
X |
Number of dead animals, cannibalism, post-mortem examination if applicable |
X |
X |
Other striking signs, such as wound sores |
X |
X |
Clinical symptoms (tremors, cramps, limbo, etc.) |
X |
X |
Depending on the type of genetic modification: other specific morphological features |
X |
X |
Behaviour during cage change (apathy, spawning, etc.) |
X |
|
Nest construction, nest condition |
X |
|
Pelage, eyes, body orifices |
X |
|